Choice reveals that rats are majoritarily resilient to cocaine addiction
نویسندگان
چکیده
*University Bordeaux 2, Université Bordeaux 1, CNRS, M.A.C. UMR 5227, 146 rue Léo-Saignat, 33076 Bordeaux, France Current address : University Bordeaux 2, ISPED, 146 rue Léo-Saignat, 33076 Bordeaux, France. Current address : University of Miami, Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, 1600 NW 10th Ave. Miami, FL 33136 Current address : Université Bordeaux 2, NeuroCentre Magendie, U862 INSERM, 146, rue Léo Saignat 33077, Bordeaux, France Current address : Université Bordeaux 2, Laboratoire de Psychiatrie, EA 4139, 121, Rue de la Béchade, 33076 Bordeaux, France
منابع مشابه
Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction.
In standard drug self-administration settings, animals have no choice than drug use. As a result, serious doubt exists about the interpretation of drug use in experimental animals. Is it symptomatic of an underlying addiction state or merely an expectable response to lack of choice? This incertitude in turn casts a shadow over many behavioral and neurobiological changes that have been well docu...
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BACKGROUND Assessing the relative value of cocaine and how it changes with chronic drug use represents a long-standing goal in addiction research. Surprisingly, recent experiments in rats--by far the most frequently used animal model in this field--suggest that the value of cocaine is lower than previously thought. METHODOLOGY/PRINCIPAL FINDINGS Here we report a series of choice experiments t...
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RATIONALE Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their preference for cocaine over palatable food rewards. OBJECTIVES To validate the choice self-administration paradigm as a preclinical model of...
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